Nanoparticles delivery to cancer: Approaches and limitation

  • Hassan Tamam
  • Jelan A. Abdel-Aleem
  • Sayed I. Abdelrahman
  • Aly A. Abdelrahman
Keywords: Nanoparticles, nanomedicine, cancer targeting, nanoparticles delivery systems


Nanoparticles have received attention as promising delivery system of chemotherapy for cancer treatment. There are many mechanisms through which nanoparticles reaches the tumor site. Many nanoparticles delivery systems have been developed to solve problems associated with chemotherapeutic drugs such as solubility and stability or to increase tumor site specificity as by attachment of ligand to surface of nanoparticles. We provide a critical review about the factors affecting the delivery of nanoparticles to tumor site, mechanisms by which nanoparticles reach the tumor site, types of nanoparticles and limitation of nanomedicine.


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Author Biographies

Hassan Tamam

Department of Industrial Pharmacy, Faculty of Pharmacy, Assiut University, Assiut 71526, Egypt

Jelan A. Abdel-Aleem

Department of Industrial Pharmacy, Faculty of Pharmacy, Assiut University, Assiut 71526, Egypt

Sayed I. Abdelrahman

Department of Industrial Pharmacy, Faculty of Pharmacy, Assiut University, Assiut 71526, Egypt

Aly A. Abdelrahman

Department of Industrial Pharmacy, Faculty of Pharmacy, Assiut University, Assiut 71526, Egypt


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How to Cite
Hassan Tamam, Jelan A. Abdel-Aleem, Sayed I. Abdelrahman, & Aly A. Abdelrahman. (2019). Nanoparticles delivery to cancer: Approaches and limitation. IJRDO - Journal of Applied Science (ISSN: 2455-6653), 5(4), 17-44. Retrieved from