FORMULATION AND EVALUATION OF IMMEDIATE RELEASE TABLET OF ROSUVASTATIN CALCIUM BY LIQUISOLID COMPACT TECHNIQUE
Abstract
The in-vitro dissolution property of poorly water soluble Rosuvastatin calcium was improved
by exploring the potential of Liquisolid compact technique. In this technique, liquid
medications of water-insoluble drugs in liquid vehicles (non-volatile solvents) can be
converted into acceptably flowing and compressible powders. Different liquisolid compacts
were prepared using the required quantities of powder and liquid ingredients to produce
acceptably flowable and compressible admixture. To improve aqueous solubility as well as
poor dissolution rate of Rosuvastatin calcium, Propylene glycol was selected as non- volatile
Solvent, Anhydrous dibasic calcium phosphate and Syloid 244FP was selected as carrier and
coating material respectively. The formulated liquisolid system were evaluated for their
various pre-compression and post-compression parameters. From the results, it was found
that solubility and drug release increased with lower drug concentration. Optimized
formulation LS1 showed satisfactory results of cumulative percentage release (88.98±0.80%
at 30 min., 98.27±2.0% at 60 min.). The selected formulation (LS1) was found to be stable at
40 ± 0.5 °C and 75 ± 5% RH during the test period of 1 month. From this study it concludes
that, the liquisolid technique is a promising technique for improvement of dissolution
property of poorly water-soluble drugs and formulating immediate release solid dosage
forms
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