Isolation and Characterization of a Flavonone From the Leaves of Sudanese Geigeria alata(Benth and Hook)- Asteraceae

  • Abdel Karim, M Sudan University of Science and Technology
  • Mazen, I Sudan Academy
  • Khalid, M.S International University
DOI: https://doi.org/10.53555/bs.v3i7.1637
Keywords: : Isolation, Characterization, Flavanone, Geigeria alata, Antibacterial Activity

Abstract

Phytochemical screening of Geigeria alata leaves revealed the presence of flavonoids,tannins
and alkaloids. A flavonoid - compound I- was isolated from ethanol extract by column and thin
layer chromatography and its structure was established on the basis of its spectral data (IR, UV,
NMR and MS). Compound I and different fractions (ethanol, chloroform, n- butanol and ethyl
acetate) of Geigeria alata were screened for their antimicrobial activity against six standard
human pathogens. The ethyl acetate fraction showed excellent antibacterial activity against all
test organisms.However, the ethanol extract was inactive against the test bacteria ,but it gave
good antifungal activity against Aspergillus niger The chloroform and n-butanol fractions
exhibited moderate activity against Escherichia coli .

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Author Biographies

Abdel Karim, M, Sudan University of Science and Technology

Sudan University of Science and Technology, Faculty of Science

Mazen, I, Sudan Academy

Sudan Academy of Science

Khalid, M.S, International University

International University of Africa, Faculty of Pharmacy.

Published
2017-07-31
How to Cite
Karim, M, A., I, M., & M.S, K. (2017). Isolation and Characterization of a Flavonone From the Leaves of Sudanese Geigeria alata(Benth and Hook)- Asteraceae. IJRDO - JOURNAL OF BIOLOGICAL SCIENCE, 3(7), 01-12. https://doi.org/10.53555/bs.v3i7.1637
Issue
Vol. 3 No. 7 (2017): IJRDO - Journal of Biological Science
Section
Articles

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